pI: 10.0434 |
Length (AA): 293 |
MW (Da): 34732 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 7
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
20 | 292 | 1u19 (A) | 13 | 315 | 10.00 | 0.000000000059 | 0 | 1.01 | -1.16 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, sporozoite, Oocyst, Ring, Female Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 32 hs. | Otto TD |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Sporozoite, Male Gametocyte. | Zanghi G Lasonder E |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Ortholog group members (OG5_126732)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G06460 | membrane-associated elongase-like protein |
Arabidopsis thaliana | AT3G06470 | GNS1/SUR4 membrane protein family |
Candida albicans | CaO19.6343 | one of three potential fatty acid elongase genes |
Candida albicans | CaO19.13699 | one of three potential fatty acid elongase genes |
Caenorhabditis elegans | CELE_F56H11.3 | Protein ELO-7, isoform B |
Dictyostelium discoideum | DDB_G0271066 | hypothetical protein |
Dictyostelium discoideum | DDB_G0270312 | GNS1/SUR4 family protein |
Drosophila melanogaster | Dmel_CG31522 | CG31522 gene product from transcript CG31522-RF |
Drosophila melanogaster | Dmel_CG2781 | CG2781 gene product from transcript CG2781-RA |
Drosophila melanogaster | Dmel_CG32072 | Elongase 68alpha |
Drosophila melanogaster | Dmel_CG11801 | Elongase 68beta |
Echinococcus granulosus | EgrG_000347100 | elongation of very long chain fatty acids |
Echinococcus multilocularis | EmuJ_000347100 | elongation of very long chain fatty acids |
Homo sapiens | ENSG00000118402 | ELOVL fatty acid elongase 4 |
Homo sapiens | ENSG00000197977 | ELOVL fatty acid elongase 2 |
Homo sapiens | ENSG00000164181 | ELOVL fatty acid elongase 7 |
Leishmania braziliensis | LbrM.05.1160 | fatty acid elongase, putative |
Leishmania braziliensis | LbrM.32.1310 | long chain polyunsaturated fatty acid elongation enzyme-like protein |
Leishmania donovani | LdBPK_051160.1 | elongation of very long chain fatty acids protein, putative |
Leishmania donovani | LdBPK_321220.1 | long chain polyunsaturated fatty acid elongation enzyme-like protein |
Leishmania infantum | LinJ.05.1160 | fatty acid elongase, putative |
Leishmania infantum | LinJ.32.1220 | long chain polyunsaturated fatty acid elongation enzyme-like protein |
Leishmania major | LmjF.32.1160 | long chain polyunsaturated fatty acid elongation enzyme-like protein |
Leishmania major | LmjF.05.1170 | fatty acid elongase, putative |
Leishmania mexicana | LmxM.05.1170 | elongation of very long chain fatty acids protein, putative |
Leishmania mexicana | LmxM.31.1160 | long chain polyunsaturated fatty acid elongation enzyme-like protein |
Mus musculus | ENSMUSG00000021696 | ELOVL family member 7, elongation of long chain fatty acids (yeast) |
Mus musculus | ENSMUSG00000021364 | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 |
Mus musculus | ENSMUSG00000032262 | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 |
Neospora caninum | NCLIV_017540 | elongation of very long chain fatty acids 4 protein, putative |
Plasmodium berghei | PBANKA_0104700 | long chain polyunsaturated fatty acid elongation enzyme, putative |
Plasmodium falciparum | PF3D7_0605900 | long chain polyunsaturated fatty acid elongation enzyme, putative |
Plasmodium knowlesi | PKNH_1144300 | long chain polyunsaturated fatty acid elongation enzyme, putative |
Plasmodium vivax | PVX_113465 | long chain polyunsaturated fatty acid elongation enzyme, putative |
Plasmodium yoelii | PY00625 | hypothetical protein |
Saccharomyces cerevisiae | YCR034W | fatty acid elongase ELO2 |
Schistosoma japonicum | Sjp_0095000 | Elongation of very long chain fatty acids protein AAEL008004, putative |
Schistosoma japonicum | Sjp_0062200 | ko:K10249 elongation of very long chain fatty acids protein 4, putative |
Schistosoma japonicum | Sjp_0314970 | Elongation of very long chain fatty acids protein 7, putative |
Schistosoma japonicum | Sjp_0044090 | ko:K10250 elongation of very long chain fatty acids protein 7, putative |
Schistosoma mansoni | Smp_010770.2 | elongation of fatty acids protein 1 |
Schistosoma mansoni | Smp_051810 | elongation of fatty acids protein 1 |
Schistosoma mansoni | Smp_010770.1 | fatty acid acyl transferase-related |
Schmidtea mediterranea | mk4.004143.00 | |
Schmidtea mediterranea | mk4.005022.00 | |
Schmidtea mediterranea | mk4.009946.01 | Elongation of very long chain fatty acids protein 4 |
Schmidtea mediterranea | mk4.054857.00 | Elongation of fatty acids protein 1 |
Schmidtea mediterranea | mk4.016012.00 | |
Schmidtea mediterranea | mk4.006666.02 | Elongation of fatty acids protein 1 |
Schmidtea mediterranea | mk4.005022.01 | |
Schmidtea mediterranea | mk4.004734.03 | |
Schmidtea mediterranea | mk4.009918.00 | Elongation of very long chain fatty acids protein 4 |
Schmidtea mediterranea | mk4.006478.00 | |
Trypanosoma brucei gambiense | Tbg972.5.6070 | elongation of very long chain fatty acids protein, putative |
Trypanosoma brucei | Tb05.5K5.170 | elongation of very long chain fatty acids protein, putative |
Trypanosoma brucei | Tb927.5.4530 | Long chain fatty acyl elongase |
Trypanosoma congolense | TcIL3000_5_5220 | elongation of very long chain fatty acids protein, putative |
Trypanosoma cruzi | TcCLB.509539.30 | fatty acid elongase, putative |
Trypanosoma cruzi | TcCLB.506717.10 | fatty acid elongase, putative |
Toxoplasma gondii | TGME49_242380 | fatty acid elongase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.4530 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.4530 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.4530 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.5.4530 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0104700 | Plasmodium berghei | Dispensable | plasmo |
TGME49_242380 | Toxoplasma gondii | Essentiality uncertain | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | ELOVL fatty acid elongase 2 | Compounds | References |